Release form, composition and packing
Cream for topical use of 0.1% mometasone furoate 1 g 1 mg. Other ingredients: hexylene glycol, phosphoric acid, propylene glycol stearate, stearyl alcohol, tsetilstearilovy ether ceteareth-20, titanium dioxide, aluminum oktenilsuktsinat (derived from starch), white wax, white petrolatum, purified water.
Lotion 0.1% mometasone furoate 1 ml of 1 mg. Other ingredients: Isopropyl alcohol 40% propylene glycol, hydroxypropyl cellulose, sodium dihydrogen phosphate dihydrate, phosphoric acid (to determine pH 3.5 – 5.5), water.
Ointment for external application of 0.1% mometasone furoate 1 g 1 mg. Other ingredients: hexylene glycol, phosphoric acid, propylene glycol stearate, white wax, white petrolatum, purified water.
Clinico-pharmacological group: SCS for outdoor use.
Pharmacological action Furoate Cream
SCS for outdoor use. Has anti-inflammatory, antipruritic and antiexudative action. GCS induce isolation of proteins that inhibit phospholipase A2, and collectively known as lipokortiny that control the biosynthesis of inflammatory mediators as prostaglandins and leukotrienes, by inhibiting the release of their common precursor, arachidonic acid.
Pharmacokinetics Furoate Cream
Absorption of a cream, ointment and lotion is negligible. After 8 hours after application to intact skin (non-occlusive dressings) into the systemic circulation is detected 0.4% furoate cream and using 0.7% mometasone using the ointment and lotion.
Statement Furoate Cream
For cream and ointment
• inflammatory reactions and pruritus in dermatoses, treatable SCS.
Lotion
• inflammatory reactions and pruritus in dermatoses amenable to therapy, corticosteroids (including psoriasis), with the defeat of hairy areas of skin.
Dosing regimen Furoate Cream
Cream or ointment applied thinly to the affected skin 1 time per day. A few drops of lotion applied to affected skin 1 time per day, and after applying lotion rubbed soft movements before his disappearance from the skin surface.
For the most efficient and economical use of lotion should bring a bottle nose closer to the affected skin and gently squeeze the bottle. The duration of treatment is determined by its efficiency, and tolerance by patients, the presence and severity of side effects.
Side effect Furoate Cream
Local reactions: seldom – irritation and dryness, burning sensation, pruritus, folliculitis, hypertrichosis, acne, hypopigmentation, perioral dermatitis, allergic contact dermatitis, joining a secondary infection, skin maceration, the signs of skin atrophy, striae, miliaria, less than 1% – the formation of papules, pustules.
• When applying the external forms of corticosteroids for a long time and / or to treat large areas of skin, or with occlusive dressings, especially in children and adolescents may experience side effects typical of systemic corticosteroids, including adrenal insufficiency and Cushing’s syndrome.
Contraindications Furoate Cream
• rosacea, perioral dermatitis;
• bacterial, viral (Herpes simplex, Nerpes zoster, varicella), fungal infection of the skin;
• tuberculosis;
• Syphilis;
• post-vaccination reactions;
• children up to age 2 years;
• pregnancy (use for large areas of skin, long-term treatment);
• Lactation (used in large doses and / or for a long time);
• Hypersensitivity to the drug or the SCS.
Caution should be applied to the drug on the skin and intertriginoznuyu skin, use occlusive dressings, and also to apply to large areas of skin and / or for a long time (especially in children).
Pregnancy and lactation Furoate Cream
Mometasone furoate safety of pregnancy and lactation has not been studied. GCS penetrate the placental barrier. Should avoid prolonged treatment and high doses in pregnancy due to the risk of adverse effects on fetal development. Corticosteroids are excreted in breast milk. If necessary, use of corticosteroids in high doses and / or for a long time, you should stop breastfeeding.
Cautions
When applied to large areas of skin for a long time, especially when using occlusive dressings, corticosteroids may come into contact in the systemic circulation and the development of systemic corticosteroids. Given this, patients should be observed for signs of suppressing the function of the hypothalamic-pituitary-adrenal system and the development of Cushing’s syndrome. Avoid getting product into eyes. Propylene glycol, which is part of the drug, may cause irritation at the site of application, and isopropanol – a burning sensation in contact with inflamed skin. In such cases, discontinue use Elocon Cream and appropriate treatment.
Keep in mind that the SSC can change the manifestations of certain skin diseases that can complicate diagnosis. In addition, the use of corticosteroids may cause a delay of wound healing. Long-term therapy of GCS sudden cessation of therapy may lead to rebound syndrome, which manifests itself in the form of dermatitis with intense redness and burning sensation. So after a long course of treatment abolition of the drug should be made gradually, for example, going to the intermittent regimen, before it completely stopped.
Use in pediatrics Furoate Cream
Due to the fact that in children the value of the ratio of surface area and body weight than adults, children are at greater risk of suppressing the function of the hypothalamic-pituitary-adrenal system and the development of Cushing’s syndrome in the application of any topical corticosteroids. Prolonged use of corticosteroids in children may lead to violations of their growth and development. Children should receive the minimum dose sufficient to achieve the effect.
Overdose Furoate Cream
Symptoms: depression of the function of the hypothalamic-pituitary-adrenal system, including secondary adrenal insufficiency. Treatment: symptomatic, if necessary – correction of electrolyte imbalance, the removal of the drug (long-term therapy – the phasing out).
Drug Interactions Furoate Cream
Interaction data Elocon Cream with other drugs are not available.
Conditions and terms of
The drug should be stored in a place inaccessible to children at 2 ° to 25 ° C. Shelf life Cream – 2 years, ointment and lotion – 3 years.
